Skip to main content

RhoGEF domain









RhoGEF domain


From Wikipedia, the free encyclopedia



Revision as of 16:03, 10 November 2018 by Kalafati(talk | contribs) (added link to CDD)


(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)


Jump to navigation
Jump to search







































RhoGEF domain

PDB 1dbh EBI.jpg
Structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein.[1]

Identifiers
Symbol RhoGEF
Pfam PF00621
InterPro IPR000219
SMART RhoGEF
SCOP 1dbh
SUPERFAMILY 1dbh
OPM protein 1xd4
CDD cd00160















RhoGEF domain is a structural domain of guanine nucleotide exchange factors for Rho/Rac/Cdc42-like GTPases. It is also called "Dbl-homologous" (DH) domain.




Contents






  • 1 Subfamilies


  • 2 Human proteins containing this domain


  • 3 References


  • 4 Further reading




Subfamilies



  • Guanine-nucleotide dissociation stimulator, CDC24 InterPro: IPR001331

Human proteins containing this domain


ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15;
ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF3; ARHGEF4; ARHGEF5;
ARHGEF6; ARHGEF7; ARHGEF9; ASEF2; BCR; C9orf100; DEPDC2; DNMBP;
ECT2; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5;
FGD6; GEFT; ITSN1; ITSN2; KALRN; LFDH; MCF2; MCF2L;
MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4;
PLEKHG5; PLEKHG6; PREX1; RASGRF1; SGEF; SOS1; SOS2; SPATA13;
TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3;


References





  1. ^ Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein". Cell. 95 (2): 259–68. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}



Further reading


.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}



  • Cerione RA, Zheng Y (April 1996). "The Dbl family of oncogenes". Current Opinion in Cell Biology. 8 (2): 216–22. doi:10.1016/s0955-0674(96)80068-8. PMID 8791419.


  • Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA (November 1991). "Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product". Nature. 354 (6351): 311–4. doi:10.1038/354311a0. PMID 1956381.


  • Tan EC, Leung T, Manser E, Lim L (December 1993). "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins". The Journal of Biological Chemistry. 268 (36): 27291–8. PMID 8262969.


  • Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein". Cell. 95 (2): 259–68. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.











Retrieved from "https://en.wikipedia.org/w/index.php?title=RhoGEF_domain&oldid=868189423"





Navigation menu

























(window.RLQ=window.RLQ||).push(function(){mw.config.set({"wgPageParseReport":{"limitreport":{"cputime":"0.236","walltime":"0.301","ppvisitednodes":{"value":673,"limit":1000000},"ppgeneratednodes":{"value":0,"limit":1500000},"postexpandincludesize":{"value":28021,"limit":2097152},"templateargumentsize":{"value":441,"limit":2097152},"expansiondepth":{"value":10,"limit":40},"expensivefunctioncount":{"value":1,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":11348,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 259.097 1 -total"," 55.28% 143.233 5 Template:Cite_journal"," 48.50% 125.657 1 Template:Reflist"," 28.47% 73.764 2 Template:Infobox"," 27.26% 70.624 1 Template:Pfam_box"," 6.30% 16.335 1 Template:Membrane-protein-stub"," 5.33% 13.800 1 Template:Asbox"," 4.75% 12.318 1 Template:Refbegin"," 1.34% 3.463 2 Template:Main_other"," 1.22% 3.168 2 Template:Template_other"]},"scribunto":{"limitreport-timeusage":{"value":"0.145","limit":"10.000"},"limitreport-memusage":{"value":3022243,"limit":52428800}},"cachereport":{"origin":"mw1333","timestamp":"20190211040548","ttl":2073600,"transientcontent":false}}});});{"@context":"https://schema.org","@type":"Article","name":"RhoGEF domain","url":"https://en.wikipedia.org/wiki/RhoGEF_domain","sameAs":"http://www.wikidata.org/entity/Q7320800","mainEntity":"http://www.wikidata.org/entity/Q7320800","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https://www.wikimedia.org/static/images/wmf-hor-googpub.png"}},"datePublished":"2007-12-13T02:33:54Z","dateModified":"2019-01-29T14:46:52Z","image":"https://upload.wikimedia.org/wikipedia/commons/b/bc/PDB_1dbh_EBI.jpg"}(window.RLQ=window.RLQ||).push(function(){mw.config.set({"wgBackendResponseTime":494,"wgHostname":"mw1333"});});

Popular posts from this blog

Human spaceflight

Can not write log (Is /dev/pts mounted?) - openpty in Ubuntu-on-Windows?

張江高科駅