Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product
<!--
Thank you for visiting nature.com. You are using a browser version with
limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off
compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site
without styles and JavaScript.
Letter
|
Published: 28 November 1991
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product
Naturevolume 354, pages311–314
(1991)
|
Download Citation
Subjects
Abstract
THE superfamily of low molecular mass GTP-binding proteins, for which the ras proteins are prototypes, has been implicated in the regulation of diverse biological activities including protein trafficking, secretion, and cell growth and differentiation1–3. One member of this family, CDC42Hs (originally referred to as Gp or G25K)4,5, seems to be the human homologue of the Saccharomyces cerevisiae cell-division-cycle protein, CDC42Sc(refs 6–9). A second S. cerevisiae protein, CDC24 (ref. 10), which is known from complementation studies to act with CDC42Sc to regulate the development of normal cell shape and the selection of nonran-dom budding sites in yeast, contains a region with sequence similarity to the dbl oncogene product11–14. Here we show that dbl specifically catalyses the dissociation of GDP from CDC42Hsand thereby qualifies as a highly selective guanine nucleotide exchange factor for the GTP-binding protein. Although guanine nucleotide exchange activities have been previously described for other members of the Ras-related GTP-binding protein family15–17, this is the first demonstration, to our knowledge, of the involvement of a human oncogenic protein in catalysing exchange activity.
Access options
/* style specs start */
style{display:none!important}.LiveAreaSection-193358632 *{align-content:stretch;align-items:stretch;align-self:auto;animation-delay:0s;animation-direction:normal;animation-duration:0s;animation-fill-mode:none;animation-iteration-count:1;animation-name:none;animation-play-state:running;animation-timing-function:ease;azimuth:center;backface-visibility:visible;background-attachment:scroll;background-blend-mode:normal;background-clip:borderBox;background-color:transparent;background-image:none;background-origin:paddingBox;background-position:0 0;background-repeat:repeat;background-size:auto auto;block-size:auto;border-block-end-color:currentcolor;border-block-end-style:none;border-block-end-width:medium;border-block-start-color:currentcolor;border-block-start-style:none;border-block-start-width:medium;border-bottom-color:currentcolor;border-bottom-left-radius:0;border-bottom-right-radius:0;border-bottom-style:none;border-bottom-width:medium;border-collapse:separate;border-image-outset:0s;border-image-repeat:stretch;border-image-slice:100%;border-image-source:none;border-image-width:1;border-inline-end-color:currentcolor;border-inline-end-style:none;border-inline-end-width:medium;border-inline-start-color:currentcolor;border-inline-start-style:none;border-inline-start-width:medium;border-left-color:currentcolor;border-left-style:none;border-left-width:medium;border-right-color:currentcolor;border-right-style:none;border-right-width:medium;border-spacing:0;border-top-color:currentcolor;border-top-left-radius:0;border-top-right-radius:0;border-top-style:none;border-top-width:medium;bottom:auto;box-decoration-break:slice;box-shadow:none;box-sizing:border-box;break-after:auto;break-before:auto;break-inside:auto;caption-side:top;caret-color:auto;clear:none;clip:auto;clip-path:none;color:initial;column-count:auto;column-fill:balance;column-gap:normal;column-rule-color:currentcolor;column-rule-style:none;column-rule-width:medium;column-span:none;column-width:auto;content:normal;counter-increment:none;counter-reset:none;cursor:auto;display:inline;empty-cells:show;filter:none;flex-basis:auto;flex-direction:row;flex-grow:0;flex-shrink:1;flex-wrap:nowrap;float:none;font-family:initial;font-feature-settings:normal;font-kerning:auto;font-language-override:normal;font-size:medium;font-size-adjust:none;font-stretch:normal;font-style:normal;font-synthesis:weight style;font-variant:normal;font-variant-alternates:normal;font-variant-caps:normal;font-variant-east-asian:normal;font-variant-ligatures:normal;font-variant-numeric:normal;font-variant-position:normal;font-weight:400;grid-auto-columns:auto;grid-auto-flow:row;grid-auto-rows:auto;grid-column-end:auto;grid-column-gap:0;grid-column-start:auto;grid-row-end:auto;grid-row-gap:0;grid-row-start:auto;grid-template-areas:none;grid-template-columns:none;grid-template-rows:none;height:auto;hyphens:manual;image-orientation:0deg;image-rendering:auto;image-resolution:1dppx;ime-mode:auto;inline-size:auto;isolation:auto;justify-content:flexStart;left:auto;letter-spacing:normal;line-break:auto;line-height:normal;list-style-image:none;list-style-position:outside;list-style-type:disc;margin-block-end:0;margin-block-start:0;margin-bottom:0;margin-inline-end:0;margin-inline-start:0;margin-left:0;margin-right:0;margin-top:0;mask-clip:borderBox;mask-composite:add;mask-image:none;mask-mode:matchSource;mask-origin:borderBox;mask-position:0% 0%;mask-repeat:repeat;mask-size:auto;mask-type:luminance;max-height:none;max-width:none;min-block-size:0;min-height:0;min-inline-size:0;min-width:0;mix-blend-mode:normal;object-fit:fill;object-position:50% 50%;offset-block-end:auto;offset-block-start:auto;offset-inline-end:auto;offset-inline-start:auto;opacity:1;order:0;orphans:2;outline-color:initial;outline-offset:0;outline-style:none;outline-width:medium;overflow:visible;overflow-wrap:normal;overflow-x:visible;overflow-y:visible;padding-block-end:0;padding-block-start:0;padding-bottom:0;padding-inline-end:0;padding-inline-start:0;padding-left:0;padding-right:0;padding-top:0;page-break-after:auto;page-break-before:auto;page-break-inside:auto;perspective:none;perspective-origin:50% 50%;pointer-events:auto;position:static;quotes:initial;resize:none;right:auto;ruby-align:spaceAround;ruby-merge:separate;ruby-position:over;scroll-behavior:auto;scroll-snap-coordinate:none;scroll-snap-destination:0 0;scroll-snap-points-x:none;scroll-snap-points-y:none;scroll-snap-type:none;shape-image-threshold:0;shape-margin:0;shape-outside:none;tab-size:8;table-layout:auto;text-align:initial;text-align-last:auto;text-combine-upright:none;text-decoration-color:currentcolor;text-decoration-line:none;text-decoration-style:solid;text-emphasis-color:currentcolor;text-emphasis-position:over right;text-emphasis-style:none;text-indent:0;text-justify:auto;text-orientation:mixed;text-overflow:clip;text-rendering:auto;text-shadow:none;text-transform:none;text-underline-position:auto;top:auto;touch-action:auto;transform:none;transform-box:borderBox;transform-origin:50% 50% 0;transform-style:flat;transition-delay:0s;transition-duration:0s;transition-property:all;transition-timing-function:ease;vertical-align:baseline;visibility:visible;white-space:normal;widows:2;width:auto;will-change:auto;word-break:normal;word-spacing:normal;word-wrap:normal;writing-mode:horizontalTb;z-index:auto;-webkit-appearance:none;-moz-appearance:none;-ms-appearance:none;appearance:none;margin:0}.LiveAreaSection-193358632{width:100%}.LiveAreaSection-193358632 .login-option-buybox{display:block;width:100%;font-size:17px;line-height:30px;color:#222;padding-top:30px;font-family:Lora,Palatino,Times,"Times New Roman",serif}.LiveAreaSection-193358632 .additional-access-options{display:block;font-weight:700;font-size:17px;line-height:30px;color:#222;font-family:Lora,Palatino,Times,"Times New Roman",serif}.LiveAreaSection-193358632 .additional-login>li:not(:first-child)::before{transform:translateY(-50%);content:'';height:1rem;position:absolute;top:50%;left:0;border-left:2px solid #999}.LiveAreaSection-193358632 .additional-login>li:not(:first-child){padding-left:10px}.LiveAreaSection-193358632 .additional-login>li{display:inline-block;position:relative;vertical-align:middle;padding-right:10px}.BuyBoxSection-683559780{display:flex;flex-wrap:wrap;flex:1;flex-direction:row-reverse;margin:-30px -15px 0}.BuyBoxSection-683559780 .box-inner{width:100%;height:100%}.BuyBoxSection-683559780 .readcube-buybox{background-color:rgba(218,229,234,.5);flex-shrink:1;flex-grow:1;flex-basis:255px;background-clip:content-box;padding:0 15px;margin-top:30px}.BuyBoxSection-683559780 .subscribe-buybox{background-color:#dae5ea;flex-shrink:1;flex-grow:4;flex-basis:300px;background-clip:content-box;padding:0 15px;margin-top:30px}.BuyBoxSection-683559780 .title-readcube{display:block;margin:0;margin-right:20%;margin-left:20%;font-size:24px;line-height:32px;color:#222;padding-top:30px;text-align:center;font-family:Lora,Palatino,Times,"Times New Roman",serif}.BuyBoxSection-683559780 .title-buybox{display:block;margin:0;margin-right:29%;margin-left:29%;font-size:24px;line-height:32px;color:#222;padding-top:30px;text-align:center;font-family:Lora,Palatino,Times,"Times New Roman",serif}.BuyBoxSection-683559780 .title-asia-buybox{display:block;margin:0;margin-right:5%;margin-left:5%;font-size:24px;line-height:32px;color:#222;padding-top:30px;text-align:center;font-family:Lora,Palatino,Times,"Times New Roman",serif}.BuyBoxSection-683559780 .asia-link,.Link-328123652,.Link-2926870917,.Link-2291679238{color:#069;cursor:pointer;text-decoration:none;font-size:1.05em;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:1.05em6}.BuyBoxSection-683559780 .access-readcube{display:block;margin:0;margin-right:10%;margin-left:10%;font-size:14px;color:#222;padding-top:10px;text-align:center;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:20px}.BuyBoxSection-683559780 .access-asia-buybox{display:block;margin:0;margin-right:5%;margin-left:5%;font-size:14px;color:#222;padding-top:10px;text-align:center;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:20px}.BuyBoxSection-683559780 .access-buybox{display:block;margin:0;margin-right:30%;margin-left:30%;font-size:14px;color:#222;opacity:.8px;padding-top:10px;text-align:center;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:20px}.BuyBoxSection-683559780 .price-buybox{display:block;font-size:30px;color:#222;font-family:"Source Sans Pro",helvetica,sans-serif;padding-top:30px;text-align:center}.BuyBoxSection-683559780 .price-from{font-size:14px;padding-right:10px;color:#222;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:20px}.BuyBoxSection-683559780 .issue-buybox{display:block;font-size:13px;text-align:center;color:#222;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:19px}.BuyBoxSection-683559780 .no-price-buybox{display:block;font-size:13px;line-height:18px;text-align:center;padding-right:10%;padding-left:10%;padding-bottom:20px;padding-top:30px;color:#222;font-family:"Source Sans Pro",helvetica,sans-serif}.BuyBoxSection-683559780 .vat-buybox{display:block;margin-top:5px;margin-right:20%;margin-left:20%;font-size:11px;color:#222;padding-top:10px;padding-bottom:15px;text-align:center;font-family:"Source Sans Pro",helvetica,sans-serif;line-height:17px}.BuyBoxSection-683559780 .button-container{display:block;padding-right:20px;padding-left:20px}.BuyBoxSection-683559780 .button-container>a:hover,.Button-505204839:hover,.Button-1078489254:hover{text-decoration:none}.BuyBoxSection-683559780 .readcube-button{background:#fff;margin-top:30px}.BuyBoxSection-683559780 .button-asia{background:#069;border:1px solid #069;border-radius:0;cursor:pointer;display:block;padding:9px;outline:0;text-align:center;text-decoration:none;min-width:80px;margin-top:75px}.BuyBoxSection-683559780 .button-label-asia,.ButtonLabel-3869432492,.ButtonLabel-3296148077{display:block;color:#fff;font-size:17px;line-height:20px;font-family:"Source Sans Pro",helvetica,sans-serif;text-align:center;text-decoration:none;cursor:pointer}.Button-505204839,.Button-1078489254{background:#069;border:1px solid #069;border-radius:0;cursor:pointer;display:block;padding:9px;outline:0;text-align:center;text-decoration:none;min-width:80px;margin-top:10px}.Button-505204839 .readcube-label,.Button-1078489254 .readcube-label{color:#069}.uList-2102244549{list-style:none;padding:0;margin:0}
/* style specs end */
Subscribe to Journal
Get full journal access for 1 year
227,39 €
only 4,46 € per issue
All prices include VAT for Cyprus.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.
References
1Hall, A. Science 249, 635–640 (1990).
2Bourne, H. R., Sanders, D. A. & McCormick, F. Nature 348, 125–132 (1990).
3Evans, T., Hart, M. J. & Cerione, R. A. Curr. Opinion Cell Biol. 3, 185–191 (1991).
4Evans, T., Brown, M. L., Fraser, E. D. & Northup, J. K. J. biol. Chem. 261, 7052–7056 (1986).
5Polakis, P. G., Snyderman, R. & Evans, T. Biochem. biophys. Res. Commun. 160, 25–32 (1989).
6Adams, A. E. M., Johnson, D. I., Longnecker, R. M., Sloat, B. F. & Pringle, J. R. J. Cell Biol. 111, 131–142 (1990).
7Johnson, D. I. & Pringle, J. R. J. Cell Biol. 111, 143–152 (1990).
8Munemitsu, S. et al. Molec. cell. Biol. 10, 5977–5982 (1990).
9Shinjo, K. et al. Proc. natn. Acad. Sci. U.S.A. 87, 9853–9857 (1990).
10Sloat, B. F., Adams, A. & Pringle, J. R. J. Cell Biol. 89, 395–405 (1981).
11Eva, A. & Aaronson, S. A. Nature 316, 273–275 (1985).
12Ron, D., Tronick, S. R., Aaronson, S. A. & Eva, A. EMBO J. 7, 2465–2473 (1988).
13Eva, A., Vecchio, G., Rao, C. D., Tronick, S. R. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 85, 2061–2065 (1988).
14Ron, D. et al. New Biologist, 3, 372–379 (1991).
15Wolfman, A. & Macara, I. G. Science 248, 67–69 (1990).
16Huang, Y. K., Kung, H.-F. & Kamata, T. Proc. natn. Acad. Sci. U.S.A. 87, 8008–8012 (1990).
17Yamamoto, T. et al. J. biol. Chem. 265, 16626–16634 (1990).
18Graziani, G., Nebreda, A., Srivastava, S. K., Santos, E. & Eva, A. Oncogene (in the press).
19Hart, M. J., Shinjo, K., Hall, A., Evans, T. & Cerione, R. A. J. biol. Chem. (in the press).
20Graziani, G., Ron, D., Eva, A. & Srivastava, S. K. Oncogene 4, 823–829 (1989).
21Hart, M. J., Polakis, P. G., Evans, T. & Cerione, R. A. J. biol. Chem. 265, 5990–6001 (1990).
22Polakis, P. G. et al. J. biol. Chem. 264, 16378–16382 (1989).
Author information
Affiliations
Department of Biochemistry, Cellular and Molecular Biology, and Department of Pharmacology, Cornell University, Ithaca, New York, 14853, USA
- Matthew J. Hart
- & Richard A. Cerione
Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, 20892, USA
- Alessandra Eva
- & Stuart A. Aaronson
Department of Cell Biology, Genentech Inc., 460 Pt San Bruno Boulevard, South San Francisco, California, 94080, USA
- Tony Evans
Authors
Search for Matthew J. Hart in:
Nature Research journals •
PubMed •
Google Scholar
Search for Alessandra Eva in:
Nature Research journals •
PubMed •
Google Scholar
Search for Tony Evans in:
Nature Research journals •
PubMed •
Google Scholar
Search for Stuart A. Aaronson in:
Nature Research journals •
PubMed •
Google Scholar
Search for Richard A. Cerione in:
Nature Research journals •
PubMed •
Google Scholar
Rights and permissions
To obtain permission to re-use content from this article visit RightsLink.
About this article
Publication history
Received
18 July 1991
Accepted
30 September 1991
Issue Date
28 November 1991
DOI
https://doi.org/10.1038/354311a0
Further reading
Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease
Oncogene
(2014)
G protein alpha 12
AfCS-Nature Molecule Pages
(2010)
RhoA
AfCS-Nature Molecule Pages
(2009)
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
Nature Structural & Molecular Biology
(2009)
Mutational analysis of proto-oncogene Dbl on Xq27 in testicular germ cell tumors reveals a rare SNP in a patient with bilateral undescended testis
World Journal of Urology
(2009)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
var readingCompanionData = {
"sections" : [ {
"id" : "Abs1",
"title" : "Abstract"
}, {
"id" : "Bib1",
"title" : "References"
}, {
"id" : "author-information",
"title" : "Author information"
}, {
"id" : "rightslink",
"title" : "Rights and permissions"
}, {
"id" : "article-info",
"title" : "About this article"
}, {
"id" : "further-reading",
"title" : "Further reading"
}, {
"id" : "article-comments",
"title" : "Comments",
"extraClass" : "hide"
} ],
"figures" : [ ],
"references" : [ {
"id" : "-CR1",
"title" : "Hall, A. Science 249, 635–640 (1990).",
"number" : "1",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Sci...249..635H"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3cXltFaku7Y%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1126%2Fscience.2116664"
} ],
"journalTitle" : "Science",
"authors" : [ {
"initials" : "A",
"familyName" : "Hall"
} ],
"year" : "1990",
"doi" : "10.1126/science.2116664"
}, {
"id" : "-CR2",
"title" : "Bourne, H. R., Sanders, D. A. & McCormick, F. Nature 348, 125–132 (1990).",
"number" : "2",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Natur.348..125B"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3MXhvFyjtQ%253D%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1038%2F348125a0"
} ],
"journalTitle" : "Nature",
"authors" : [ {
"initials" : "HR",
"familyName" : "Bourne"
}, {
"initials" : "DA",
"familyName" : "Sanders"
}, {
"initials" : "F",
"familyName" : "McCormick"
} ],
"year" : "1990",
"doi" : "10.1038/348125a0"
}, {
"id" : "-CR3",
"title" : "Evans, T., Hart, M. J. & Cerione, R. A. Curr. Opinion Cell Biol. 3, 185–191 (1991).",
"number" : "3",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3MXltVyltLs%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1016%2F0955-0674%2891%2990137-N"
} ],
"journalTitle" : "Curr. Opinion Cell Biol.",
"authors" : [ {
"initials" : "T",
"familyName" : "Evans"
}, {
"initials" : "MJ",
"familyName" : "Hart"
}, {
"initials" : "RA",
"familyName" : "Cerione"
} ],
"year" : "1991",
"doi" : "10.1016/0955-0674(91)90137-N"
}, {
"id" : "-CR4",
"title" : "Evans, T., Brown, M. L., Fraser, E. D. & Northup, J. K. J. biol. Chem. 261, 7052–7056 (1986).",
"number" : "4",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL28Xkt1Witbg%253D"
}, {
"name" : "PubMed",
"url" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=3084494"
} ],
"journalTitle" : "J. biol. Chem.",
"authors" : [ {
"initials" : "T",
"familyName" : "Evans"
}, {
"initials" : "ML",
"familyName" : "Brown"
}, {
"initials" : "ED",
"familyName" : "Fraser"
}, {
"initials" : "JK",
"familyName" : "Northup"
} ],
"year" : "1986"
}, {
"id" : "-CR5",
"title" : "Polakis, P. G., Snyderman, R. & Evans, T. Biochem. biophys. Res. Commun. 160, 25–32 (1989).",
"number" : "5",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL1MXitVyjtLY%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1016%2F0006-291X%2889%2991615-X"
} ],
"journalTitle" : "Biochem. biophys. Res. Commun.",
"authors" : [ {
"initials" : "PG",
"familyName" : "Polakis"
}, {
"initials" : "R",
"familyName" : "Snyderman"
}, {
"initials" : "T",
"familyName" : "Evans"
} ],
"year" : "1989",
"doi" : "10.1016/0006-291X(89)91615-X"
}, {
"id" : "-CR6",
"title" : "Adams, A. E. M., Johnson, D. I., Longnecker, R. M., Sloat, B. F. & Pringle, J. R. J. Cell Biol. 111, 131–142 (1990).",
"number" : "6",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3cXkslClsr8%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1083%2Fjcb.111.1.131"
} ],
"journalTitle" : "J. Cell Biol.",
"authors" : [ {
"initials" : "AEM",
"familyName" : "Adams"
}, {
"initials" : "DI",
"familyName" : "Johnson"
}, {
"initials" : "RM",
"familyName" : "Longnecker"
}, {
"initials" : "BF",
"familyName" : "Sloat"
}, {
"initials" : "JR",
"familyName" : "Pringle"
} ],
"year" : "1990",
"doi" : "10.1083/jcb.111.1.131"
}, {
"id" : "-CR7",
"title" : "Johnson, D. I. & Pringle, J. R. J. Cell Biol. 111, 143–152 (1990).",
"number" : "7",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3cXlt1Ontbk%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1083%2Fjcb.111.1.143"
} ],
"journalTitle" : "J. Cell Biol.",
"authors" : [ {
"initials" : "DI",
"familyName" : "Johnson"
}, {
"initials" : "JR",
"familyName" : "Pringle"
} ],
"year" : "1990",
"doi" : "10.1083/jcb.111.1.143"
}, {
"id" : "-CR8",
"title" : "Munemitsu, S. et al. Molec. cell. Biol. 10, 5977–5982 (1990).",
"number" : "8",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3MXhsl2gsL8%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1128%2FMCB.10.11.5977"
} ],
"journalTitle" : "Molec. cell. Biol.",
"authors" : [ {
"initials" : "S",
"familyName" : "Munemitsu"
} ],
"year" : "1990",
"doi" : "10.1128/MCB.10.11.5977"
}, {
"id" : "-CR9",
"title" : "Shinjo, K. et al. Proc. natn. Acad. Sci. U.S.A. 87, 9853–9857 (1990).",
"number" : "9",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990PNAS...87.9853S"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3MXktVais7s%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1073%2Fpnas.87.24.9853"
} ],
"journalTitle" : "Proc. natn. Acad. Sci. U.S.A.",
"authors" : [ {
"initials" : "K",
"familyName" : "Shinjo"
} ],
"year" : "1990",
"doi" : "10.1073/pnas.87.24.9853"
}, {
"id" : "-CR10",
"title" : "Sloat, B. F., Adams, A. & Pringle, J. R. J. Cell Biol. 89, 395–405 (1981).",
"number" : "10",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL3MXkvFeltr0%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1083%2Fjcb.89.3.395"
} ],
"journalTitle" : "J. Cell Biol.",
"authors" : [ {
"initials" : "BF",
"familyName" : "Sloat"
}, {
"initials" : "A",
"familyName" : "Adams"
}, {
"initials" : "JR",
"familyName" : "Pringle"
} ],
"year" : "1981",
"doi" : "10.1083/jcb.89.3.395"
}, {
"id" : "-CR11",
"title" : "Eva, A. & Aaronson, S. A. Nature 316, 273–275 (1985).",
"number" : "11",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1985Natur.316..273E"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL2MXltFOgsLg%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1038%2F316273a0"
} ],
"journalTitle" : "Nature",
"authors" : [ {
"initials" : "A",
"familyName" : "Eva"
}, {
"initials" : "SA",
"familyName" : "Aaronson"
} ],
"year" : "1985",
"doi" : "10.1038/316273a0"
}, {
"id" : "-CR12",
"title" : "Ron, D., Tronick, S. R., Aaronson, S. A. & Eva, A. EMBO J. 7, 2465–2473 (1988).",
"number" : "12",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL1MXovFKntg%253D%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1002%2Fj.1460-2075.1988.tb03093.x"
} ],
"journalTitle" : "EMBO J.",
"authors" : [ {
"initials" : "D",
"familyName" : "Ron"
}, {
"initials" : "SR",
"familyName" : "Tronick"
}, {
"initials" : "SA",
"familyName" : "Aaronson"
}, {
"initials" : "A",
"familyName" : "Eva"
} ],
"year" : "1988",
"doi" : "10.1002/j.1460-2075.1988.tb03093.x"
}, {
"id" : "-CR13",
"title" : "Eva, A., Vecchio, G., Rao, C. D., Tronick, S. R. & Aaronson, S. A. Proc. natn. Acad. Sci. U.S.A. 85, 2061–2065 (1988).",
"number" : "13",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1988PNAS...85.2061E"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL1cXlt1ensLk%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1073%2Fpnas.85.7.2061"
} ],
"journalTitle" : "Proc. natn. Acad. Sci. U.S.A.",
"authors" : [ {
"initials" : "A",
"familyName" : "Eva"
}, {
"initials" : "G",
"familyName" : "Vecchio"
}, {
"initials" : "CD",
"familyName" : "Rao"
}, {
"initials" : "SR",
"familyName" : "Tronick"
}, {
"initials" : "SA",
"familyName" : "Aaronson"
} ],
"year" : "1988",
"doi" : "10.1073/pnas.85.7.2061"
}, {
"id" : "-CR14",
"title" : "Ron, D. et al. New Biologist, 3, 372–379 (1991).",
"number" : "14",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3MXmslWqu7Y%253D"
} ],
"journalTitle" : "New Biologist",
"authors" : [ {
"initials" : "D",
"familyName" : "Ron"
} ],
"year" : "1991"
}, {
"id" : "-CR15",
"title" : "Wolfman, A. & Macara, I. G. Science 248, 67–69 (1990).",
"number" : "15",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990Sci...248...67W"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3cXitlWgu7s%253D"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1126%2Fscience.2181667"
} ],
"journalTitle" : "Science",
"authors" : [ {
"initials" : "A",
"familyName" : "Wolfman"
}, {
"initials" : "IG",
"familyName" : "Macara"
} ],
"year" : "1990",
"doi" : "10.1126/science.2181667"
}, {
"id" : "-CR16",
"title" : "Huang, Y. K., Kung, H.-F. & Kamata, T. Proc. natn. Acad. Sci. U.S.A. 87, 8008–8012 (1990).",
"number" : "16",
"links" : [ {
"name" : "ADS",
"url" : "http://adsabs.harvard.edu/cgi-bin/nph-data_query?link_type=ABSTRACT&bibcode=1990PNAS...87.8008H"
}, {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3MXitl2h"
}, {
"name" : "Article",
"url" : "https://doi.org/10.1073%2Fpnas.87.20.8008"
} ],
"journalTitle" : "Proc. natn. Acad. Sci. U.S.A.",
"authors" : [ {
"initials" : "YK",
"familyName" : "Huang"
}, {
"initials" : "H-F",
"familyName" : "Kung"
}, {
"initials" : "T",
"familyName" : "Kamata"
} ],
"year" : "1990",
"doi" : "10.1073/pnas.87.20.8008"
}, {
"id" : "-CR17",
"title" : "Yamamoto, T. et al. J. biol. Chem. 265, 16626–16634 (1990).",
"number" : "17",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3cXlvVKrt7k%253D"
}, {
"name" : "PubMed",
"url" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2118909"
} ],
"journalTitle" : "J. biol. Chem.",
"authors" : [ {
"initials" : "T",
"familyName" : "Yamamoto"
} ],
"year" : "1990"
}, {
"id" : "-CR18",
"title" : "Graziani, G., Nebreda, A., Srivastava, S. K., Santos, E. & Eva, A. Oncogene (in the press).",
"number" : "18",
"links" : [ ],
"authors" : [ ]
}, {
"id" : "-CR19",
"title" : "Hart, M. J., Shinjo, K., Hall, A., Evans, T. & Cerione, R. A. J. biol. Chem. (in the press).",
"number" : "19",
"links" : [ ],
"authors" : [ ]
}, {
"id" : "-CR20",
"title" : "Graziani, G., Ron, D., Eva, A. & Srivastava, S. K. Oncogene 4, 823–829 (1989).",
"number" : "20",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaL1MXlsFSqtrs%253D"
}, {
"name" : "PubMed",
"url" : "http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=2666904"
} ],
"journalTitle" : "Oncogene",
"authors" : [ {
"initials" : "G",
"familyName" : "Graziani"
}, {
"initials" : "D",
"familyName" : "Ron"
}, {
"initials" : "A",
"familyName" : "Eva"
}, {
"initials" : "SK",
"familyName" : "Srivastava"
} ],
"year" : "1989"
}, {
"id" : "-CR21",
"title" : "Hart, M. J., Polakis, P. G., Evans, T. & Cerione, R. A. J. biol. Chem. 265, 5990–6001 (1990).",
"number" : "21",
"links" : [ {
"name" : "CAS",
"url" : "/articles/cas-redirect/1%3ACAS%3A528%3ADyaK3cXhvFaltr8%253D"
} ],
"journalTitle" : "J. biol. Chem.",
"authors" : [ {
"initials" : "MJ",
"familyName" : "Hart"
}, {
"initials" : "PG",
"familyName" : "Polakis"
}, {
"initials" : "T",
"familyName" : "Evans"
}, {
"initials" : "RA",
"familyName" : "Cerione"
} ],
"year" : "1990"
}, {
"id" : "-CR22",
"title" : "Polakis, P. G. et al. J. biol. Chem. 264, 16378–16382 (1989).",
"number" : "22",
"links" : [ ],
"journalTitle" : "J. biol. Chem.",
"authors" : [ {
"initials" : "PG",
"familyName" : "Polakis"
} ],
"year" : "1989"
} ],
"hasAccess" : false,
"hasNumericReferences" : true,
"refSuffix" : null,
"video" : false
};
var backHalf = true;
var idp = {
institutionalLogin: function (names) {
if (names.length && false) {
if (document.querySelector('.js-main-column')) {
var accessMessage = document.createElement('div');
if (backHalf) {
var prependAccessMessageTo = 'div.article-body div.distractionFree'
accessMessage.innerHTML = '
Access provided by ' + names[0] + '';
document.querySelector(prependAccessMessageTo).classList.remove("visually-hidden");
document.querySelector(prependAccessMessageTo).prepend(accessMessage);
} else {
accessMessage.innerHTML = '
Access provided by ' + names[0] + '';
document.querySelector('.js-main-column').prepend(accessMessage);
}
}
}
},
hasNatureUserProof: function (hasProof) {
if (!hasProof) {
document.getElementById("my-account").setAttribute("style", "display: none;");
document.getElementById("login-button").setAttribute("style", "");
}
}
}
var appendExtraFlagsToLinks = function(params) {
$('a').filter(function(_, x) {
var href = $(x).attr('href');
return href && href.startsWith('/');
}).each(function(_, x) {
var $x = $(x);
var url = new URL('http://temp.com' + $x.attr('href'));
params.forEach(function(param) {
url.searchParams.set(param[0], param[1]);
});
$x.attr('href', url.pathname + url.search + url.hash);
});
};
var transformNatureAssetSourcesToDraft = function() {
var regex = //nature-assets//;
var targets = [['img', 'src'], ['a', 'href']];
targets.forEach(function(target) {
$(target[0]).filter(function(_, x) {
return regex.test($(x).attr(target[1]));
}).each(function(_, x) {
var $x = $(x);
$x.attr(target[1], $x.attr(target[1]).replace('nature-assets', 'nature-assets-draft'));
});
});
};
if (window.URLSearchParams) {
var params = new URLSearchParams(location.search.slice(1));
var proof = params.get('proof');
var platform = params.get('platform');
var draft = params.get('draft');
if (proof || platform || draft) {
appendExtraFlagsToLinks(
[['proof', proof], ['platform', platform], ['draft', draft]].filter(function(pair) {
return pair[1];
}));
}
if (proof || draft) {
transformNatureAssetSourcesToDraft();
}
}
